14/04/2021 – 14:00
Webinar
Indonesia, Jakarta
14/04/2021 – 15:00
EURAXESS ASEAN with International Indonesian Scholars Association
The extracellular environment defines a physical boundary condition with which cells need to negotiate. It has been known for many years that physical and mechanical cues, such as confinement substrate topography, and stretch, can dramatically alter cell phenotype. However, the scale of such effects as well as the underlying mechanisms are still poorly understood. To explore cellular response to this range of cues, our group has developed bottom-up experimental platforms that allows systematic monitoring of cellular and multicellular phenotype on a library of 2D micropatterned substrates and 3D structures in biomimetic setups. I will discuss how a rich variety of cell, tissue, and organoid responses can emerge from a physical interplay between cells and their geometrical environments, and how these responses can be exploited for biomedical applications.
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